Figure 3.

The role of Nrf2 in Mn-induced oxidative stress in glia. Nrf2 is a known regulator of the antioxidant response that translocates to the nucleus to act as a transcription factor binding to the antioxidant response element (ARE), enhancing the expression of antioxidant enzyme genes. For this to happen, it is necessary the release of Nrf2 from Keap1, such action is regulated by several effector proteins, DJ-1 is one of them. DJ-1 is downregulated in conditions of Mn overexposure, leading to the binding of Nrf2 to Keap1, promoting the degradation of Nrf2 by the ubiquitin proteasome impairing the expression of several antioxidant genes.