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. 2021 Oct 6;2021:8774663. doi: 10.1155/2021/8774663

Figure 2.

Figure 2

Acute inhibition of TRPM2 preserves LTP. (a) Time course of fEPSP slope from male juvenile mice 7 days after sham mice were administered 20 mg/kg tatSCR (black) or tatM2NX (red) 30 minutes after CA/CPR and 7 days after CA/CPR mice were administered 20 mg/kg tatSCR (blue) or tatM2NX (green) 30 min after CA/CPR. (b) Quantification of change in fEPSP slope 60 minutes after TBS stimulation normalized to 20 minutes of baseline recording. (c) Time course of fEPSP slope from female juvenile mice 7 days after sham mice were administered 20 mg/kg tatSCR (black) or tatM2NX (red) 30 minutes after CA/CPR and 7 days after CA/CPR mice were administered 20 mg/kg tatSCR (blue) or tatM2NX (green) 30 min after CA/CPR. (d) Quantification of change in fEPSP slope 60 minutes after TBS stimulation normalized to 20 minutes of baseline recording (set at 100%). Each point represents one hippocampal slice, with no more than 2 slices from an individual mouse. ∗p < 0.05 by one-way ANOVA.