Figure 4.

Delayed inhibition of TRPM2 restores memory function. (a) Quantification of freezing behavior 24 hours after contextual fear conditioning in a novel environment in mice administered 20 mg/kg tatSCR (black) or 20 mg/kg tatM2NX (red) after sham surgery or mice administered 20 mg/kg tatSCR (blue) or 20 mg/kg tatM2NX (green) 13 days after recovery from CA/CPR and behavior testing initiated on day 14 after CA/CPR. (b) Quantification of distance traveled in the same mice as in (a) in open field testing, indicating no changes in locomotion to account for differences in freezing. Each point represents 1 mouse, and ^∗p < 0.05 by one-way ANOVA.