Table 1.

Baseline characteristics at time of diagnosis and symptoms at last follow-up visit.

ID	Diagnosis	Antibodies	Age at diagnosis, sex	Time first symptoms to diagnosis/VOG	Initial symptoms	Symptoms at last follow-up (FU) visit					cMRI	Tumor	mRS
						Sleep disorder	Movement disorder	Cognition	Bulbar dysfunction	Other		y/n	Last FU
Pat.1	Anti-IgLON5 disease	S 1:400 C 1:256	64, f	2 /5 years	cognitive dysfunction, epileptic seizures	#, +	–	+	–	da, pnp	ha (b)	n	2
Pat. 2	Anti-IgLON5 disease	S 1:3200 C 1:16	72, f	5 /5 years	stridor, vocal cord palsy	#, +	+	+	+	da	le	n	4
Pat. 3	Anti-IgLON5 disease	S 1:12.800 C 1:128	77, f	10 /10 years	vertigo, gait unsteadiness	#, +	+	+	+	pnp	le	y	6
Pat. 4	Anti-IgLON5 disease	No titer available	unknown, m	14 (post mortem) /8 years	dysphagia, ataxia	#, +	+	+	+	pnp	iat	n	6
Pat. 5	PSP-RS	No	70, m	2 /2 years	dysarthria, falls, gait unsteadiness cognitive dysfunction, aphasia, tremor	#, +	+	+	+	da	le	n	6
Pat. 6	PSP-RS	No	68, m	8 / 10 years	gait unsteadiness, dysarthria, bradykinesia	*-	+	-	+	pnp	n.a.	n	4
Pat. 7	PSP-RS	No	74, m	3 /5 years	falls, bradykinesia, gait unsteadiness, rigor, dysarthria, dysphagia, extensive snoring	*+	+	-	+	-	ga	n	4
Pat. 8	PSP-RS	No	73, f	1 /1 year	falls, gait unsteadiness, dysarthria, dysphagia	*-	+	-	+	-	le	n.	6
Pat. 9	PSP-RS	No	67, f	2 /2 years	limb ataxia, gait unsteadiness, dysarthria, apraxia	*-	+	-	+	-	ca, ma	n	6
Pat. 10	PSP-P	No	66, f	2.5 / 3 years	dysphagia, dysarthria, gait unsteadiness, falls, cognitive dysfunction	*-	+	+	+	-	ga, ma, cs, ha	n	4
Pat. 11	PSP-P	No	70, f	2 / 4 years	dysphagia, dysarthria, gait unsteadiness	*, +	+	+	+	-	ga	n	5
Pat. 12	PSP-P	No	65, m	1.5 / 2 years	rigor, gait unsteadiness	*, -	+	-	+	-	le	n	4
Pat. 13	PSP-P	No	68, f	1.5 / 2 years	supranuclear gaze palsy, gait unsteadiness	*, -	+	-	+	-	ta (b)	n	4
Pat. 14	PSP-P	No	72, m	1.5 / 2 years	gait unsteadiness, falls, bradykinesia	*, -	+	+	-	-	le	n	3

Sleep disorder—confirmed by: video PSG #, by history*; movement disorder: parkinsonism, chorea, facial spasm, myoclonus, ataxia; bulbar dysfunction: dysphagia, dysarthria, stridor, vocal chord palsy, sialorrhea, respiratory failure; other: da, dysautonomia (excessive sweating, bradycardia/tachycardia), pnp, polyneuropathy; MRI: ha, hippocampal atrophy (u, unilateral; b, bilateral), ta- temporal atrophy (u, unilateral; b, bilateral), ca, cerebellar atrophy; ma, mesencephalic atrophy; cs, colibri sign; ga, generalized atrophy; le, leukoencephalopathy; iat, ischemic area thalamus; S, serum; C, cerebrospinal fluid