Table 1.
Number of mtDNA variants in iPSC clones and corresponding parental cell populations
| Donor | Haplogroup | Non-transmitted (group A) |
Transmitted (groups B + C) |
|||||
|---|---|---|---|---|---|---|---|---|
| Homoplasmic (group B) |
Heteroplasmic (group C) |
|||||||
| Polymorphisms (cat. 2) | Donor specifi (cat. 3) | Haplogroup variants (cat. 1) | Polymorphisms (cat. 2) | Donor specific (cat. 3) | Polymorphisms (cat. 2) | Donor specific (cat. 3) | ||
| D#1 hUVEC | H7a1 | 0 | 0 | 9 | 3 | 0 | 0 | 1 |
| D#2 hUVEC | H1c3 | 0 | 0 | 10 | 5 | 1 | 0 | 0 |
| D#3 hUVEC | H2a1c | 0 | 1 | 7 | 3 | 0 | 2 | 2 |
| D#4 hUVEC | J1c8a | 0 | 0 | 28 | 3 | 1 | 1 | 1 |
| D#5 hUVEC | J1b1a3 | 0 | 0 | 34 | 8 | 1 | 0 | 0 |
| D#6 hUVEC | H87 | 0 | 0 | 7 | 4 | 0 | 0 | 1 |
| Neonatal donors | mean | 0.0 | 0.2 | 15.8 | 4.3 | 0.5 | 0.5 | 0.8 |
| D#31 hSVEC | H1c2 | 4 | 0 | 9 | 4 | 0 | 0 | 2 |
| D#37 hSVEC | H10b | 0 | 0 | 8 | 3 | 0 | 4 | 6 |
| D#38 hSVEC | I3 | 3 | 0 | 32 | 4 | 0 | 1 | 0 |
| D#40 hSVEC | J1c5a | 1 | 1 | 29 | 4 | 0 | 0 | 0 |
| Aged donors | mean | 2.0 | 0.3 | 19.5 | 3.8 | 0.0 | 1.3 | 2.0 |
| Total | mean | 0.8 | 0.2 | 17.3 | 4.1 | 0.3 | 0.8 | 1.3 |
| sum | 8 | 2 | 73 | 23 | 3 | 8 | 13 | |