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CRISPR/Cas9/AAV-sgRNA-mediated in vivo genome editing uncovers the possible role of MYC in 3D genome organization in SCs
Pax7Cas9 mice were administered with AAV9-dual sgRNA virus at postnatal stage to delete MYC expression in QSCs. MYC depletion results in a global strengthening of the TAD boundaries and decrease of both of the intra- and inter-TAD interactions. The change of TAD boundary strength is associated with disrupted gene expression, which may lead to delayed SC activation.
