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. 2021 Sep 30;9:718066. doi: 10.3389/fcell.2021.718066

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Copyright © 2021 Girousi, Muerner, Parisi, Rihs, von Gunten, Katsaros and Degen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Live Imaging pictures of the in vitro scratch at the indicated times after wounding the confluent monolayer and before scratching. Left side: OKF6/TERT2; Right side: N/TERT1. Scale bar: 500 μm. (B) Quantification of the manual scratch shows a delay of the wound closure in the absence of IRF6. ^∗p < 0.05 control vs. clones. (C) Quantification of an automated live imaging scratch assay confirms impaired closure of the scratch in the IRF6 knockout keratinocytes compared to control. ^∗p < 0.05 control vs. clones. (D) Pictures of N/TERT1 control and N/TERT1 clone #10 taken at the time of scratching (0 h), 5 h, and 10 h shows that lack of IRF6 results in significantly more cells that move randomly as single cells (arrowheads, right side) compared to control (left side).