Table 2.
Risk of autoimmune disorders between PPI and non-PPI users.
| Types of Autoimmune Disorders | Event | IR | IRR | Adj. HR | 95% C.I. for adj. HR |
|---|---|---|---|---|---|
| Overall | |||||
| non-PPI | 7592 | 274.67 | ref. | ref. | |
| PPI | 2926 | 1219.94 | 4.440 | 3.640*** | 3.484–3.804 |
| Systemic | |||||
| non-PPI | 4635 | 167.65 | ref. | ref. | |
| PPI | 1858 | 772.14 | 4.606 | 4.335*** | 4.103–4.580 |
| Organ-specific | |||||
| non-PPI | 2973 | 107.38 | ref. | ref. | |
| PPI | 1075 | 445.97 | 4.148 | 2.750*** | 2.558–2.957 |
PPI, proton pump inhibitors. Adj HR, adjusted hazard ratio was adjusted by gender, age, comorbidities. IR, incidence rate was incidences of per 100,000 person-year. CI, confidence intervals. ***P-Value < 0.001.