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. 2021 Sep 2;2(6):zqab045. doi: 10.1093/function/zqab045

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© The Author(s) 2021. Published by Oxford University Press on behalf of American Physiological Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Global profiles and processes altered with MCI. Principal component analysis of of all expressed genes indicated that global profiles of genes were similar between the groups with the MCI + Med samples showing greater variability in expression (A). Comparisons between MCI and CH groups showed 138 differentially expressed genes, while donepezil-treatment revealed ∼692 differentially expressed genescompared to untreated MCI (B). Genes with a minimum 2-fold change are plotted in (C), and included HLA-B, which showed a 24-fold decrease in subjects with MCI relative to healthy controls. Gene ontology analysis showed that among genes influenced by MCI status, biological processes related to steroid biosynthesis, muscle metabolism, and lipoprotein assembly were significantly enriched (D).