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. 2021 Sep 2;2(6):zqab045. doi: 10.1093/function/zqab045

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© The Author(s) 2021. Published by Oxford University Press on behalf of American Physiological Society.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — Processes differentially affected in untreated and donepezil treated MCI subjects. Tissue-specific network analysis using the HumanBase functional module enrichment releveled fatty acid metabolism, protein–lipid catabolic process and protein biosynthetic process terms to be enriched (A) with the top 25 differentially expressed genes in this comparison are presented as a heatmap (B). Specific query of genes related to lipid transport (GO:0006869). indicated that donepezil treatment significantly altered a number of lipid transporters including increased expression of FABP3, VLDLR, APOB, and SERAC1 among others (C).