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Expression of mitochondria-related genes across groups. Expression of genes related to mitochondrial function was changed in MCI muscle and in donepezil treated individuals. This included (A) a component of succinate dehydrogenase. SDHC), (B) the largest subunit of Complex 1 (NDUFS1), (C and E) mitochondrial fusion-related proteins (MTCH2 and OPA1), (D) the master regulator of mitochondrial biogenesis (PPARGC1A), and (F) brain derived neurotrophic factor (BDNF).
