Table 1.
Participant Characteristics
| Outcome | CH (n = 24) | MCI (n = 11) | MCI + Med (n = 15) | P-value |
|---|---|---|---|---|
| Age (y) | 72.5 [8.5] | 69.6 [7.4] | 74.9 [7.3] | 0.253 |
| Sex (#, % female) | 12 [48%] | 9 [82%] | 7 (47%] | 0.128 |
| APOE4 (#, % carrier) | 9 [36%] | 8 [73%] | 7 [47%] | 0.126 |
| Education (y) | 16.9 [1.7] | 16.9 [2.3] | 15.8 [2.3] | 0.250 |
| Overweight/Obesity (#,%) | 15 [62%] | 3 [27%] | 9 [60%] | 0.130 |
| Activity per day (counts) | 12 689.8 [3470] | 14 936 [3242] | 10 121.0 [3014] | 0.010*,+ |
| VO2 peak (mL/kg/min) | 26.5 [6.9] | 25.8 [4.2] | 22.8 [6.7] | 0.155 |
| GXT duration (min) | 13.1 [2.6] | 12.4 [2.5] | 9.51 [3.3] | <0.001*,+ |
| Resting RER | 0.831 [0.08] | 0.773 [0.04] | 0.780 [0.08] | 0.031#,+ |
| Peak HR | 159.8 [20.1] | 154.9 [15.0] | 148.7 [27.4] | 0.437 |
| BMD | 1.25 [0.19] | 1.11 [0.16] | 1.20 [0.13] | 0.228 |
| Waist Hip Ratio | 0.883 [0.12] | 0.814 [0.08] | 0.917 [0.11] | 0.276 |
| Lean mass (kg) | 47.5 [10.7] | 37.9 [10.6] | 48.3 [10.4] | 0.100 |
| Fat mass (kg) | 27.0 [9.3] | 19.5 [5.1] | 29.9 [11.2] | 0.027 + |
APOE; Apolipoprotein E, BMI; body mass index, GXT; graded exercise test, RER; respiratory exchange ratio, and HR; heart rate. Mean values are given as means [SD] and were assessed using ANCOVA. P < .05 #CH vs MCI, +CH vs MCI + med, and *MCI vs MCI + med.