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. 2021 Sep 30;12:706836. doi: 10.3389/fphar.2021.706836

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Copyright © 2021 Wang, Wang, Zou, Jia, Wang, Li, Wang, Sun, Guo, Wang, Wu, Yang, Wu, Zhang and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) ELISA detection of TNF-α. (B) the ELISA detection of IL-6. (C) ELISA detection of IL-17 (note: the data are expressed as the mean ± SD (n = 3), compared with the normal group ##p < 0.01, compared with the model group, *p < 0.05, **p < 0.01). (D–I) Western blot was used to detect the protein expression levels of p-p38, p38, p-p65, p65,p-p38/p38, and p-p65/p65. (D,E) Quantitative protein expression levels of p-p38, p38, p-p65, and p65. (F,G) Protein expression level of p38, p-P38, p65, and p-P65. (H,I) Ratio of p-P38/p38 and p-P65/p65 in mouse skin lesions. (x¯±s (n = 3), compared with the normal group ###p < 0.001, ##p < 0.01, compared with the model group ***p < 0.001,*p < 0.05).