TABLE 2.
Enriched pathways in the brain.
| Term | Adjusted P | Genes |
| Female Upregulated Genes (n = 583) | ||
| Malaria | <0.001 | TGFB2;TGFB1;GYPC;HGF;ITGB2;PECAM1;CCL2;TLR4;ICAM1 |
| Hippo signaling pathway | <0.001 | YAP1;CRB2;WWTR1;TGFB2;TGFB1;FZD7;SERPINE1;ITGB2;BMP6;GLI2;TGFBR2;PARD3;CCN2;AJU BA;TEAD2 |
| PI3K-Akt signaling pathway | <0.001 | NGFR;CDKN1A;ANGPT2;CSF1;ITGB5;ITGB4;LAMB2;HGF;IGF2;GNG12;OSMR;PGF;PIK3R5;COL1A2; ITGA10;COL6A2;DDIT4;CDK2;SPP1;ITGA5;TLR4 |
| Proteoglycans in cancer | <0.001 | CDKN1A;TGFB2;TGFB1;HPSE2;ITGB5;FZD7;HGF;IGF2;DCN;MRAS;SMO;ITGA5;EZR;TLR4;CD44 |
| Human T-cell leukemia virus 1 infection | <0.001 | CDKN1A;TGFB2;TGFB1;ITGB2;NFATC2;FOS;ICAM1;NFATC4;TGFBR2;NFKBIA;ZFP36;CDK2;HLA-DRA; MSX1;HLA-DPA1 |
| Rheumatoid arthritis | <0.001 | TGFB2;TGFB1;CSF1;ITGB2;CCL2;HLA-DRA;FOS;TLR4;ICAM1;HLA-DPA1 |
| ECM-receptor interaction | <0.001 | COL1A2;ITGB5;ITGB4;LAMB2;COL6A2;ITGA10;SPP1;ITGA5;CD44 |
| Osteoclast differentiation | <0.001 | NFKBIA;SOCS3;TGFB2;TYROBP;TGFB1;CSF1;NFATC2;TNFRSF11B;TREM2;FOS;TGFBR2 |
| TGF-beta signaling pathway | <0.001 | TGIF1;TGFB2;TGIF2;TGFB1;ID4;ID3;DCN;BMP6;TGFBR2 |
| Staphylococcus aureus infection | <0.001 | C4B;C4A;ITGB2;CFI;C3AR1;HLA-DRA;ICAM1;HLA-DPA1 |
| 36 more.. | ||
| Female Downregulated Genes (n = 398) | ||
| Neuroactive ligand-receptor interaction | <0.001 | GABRA1;CHRM4;SSTR1;TACR1;HTR5A;RXFP1;GABRG2;MCHR2;ADCYAP1;MAS1;GLRA3;CCKBR; SST;GALR1;TAC3;TAC1;VIP |
| GABAergic synapse | 0.002 | PRKCG;GABRA1;GNG3;SLC32A1;GAD1;GAD2;GABRG2 |
| cAMP signaling pathway | 0.009 | ADCYAP1;PAK1;BDNF;SST;CAMK4;CALM3;SSTR1;VIP;CNGB1 |
| African trypanosomiasis | 0.02 | PRKCG;HBB;HBA2;HBA1 |
| Male Upregulated Genes (n = 415) | ||
| Focal adhesion | <0.001 | VAV3;PDGFRB;FLT1;ITGB5;LAMB2;HGF;CAV1;FN1;ELK1;PGF;COL1A2;ITGA10;COL6A2;SPP1;IT GB8;ITGA5;TLN1 |
| PI3K-Akt signaling pathway | <0.001 | PDGFRB;NGFR;CDKN1A;FLT1;ANGPT2;CSF1;ITGB5;LAMB2;HGF;FN1;IGF2;PGF;PIK3R5;COL1A2; ITGA10;COL6A2;DDIT4;SPP1;ITGB8;ITGA5;TLR4;EPHA2 |
| Proteoglycans in cancer | <0.001 | CDKN1A;TGFB2;ITGB5;HGF;CAV1;MMP2;IGF2;FN1;IQGAP1;ELK1;DCN;SMO;ITGA5;EZR;TLR4;CD44 |
| ECM-receptor interaction | <0.001 | COL1A2;ITGB5;LAMB2;COL6A2;ITGA10;SPP1;FN1;ITGB8;ITGA5;CD44 |
| MAPK signaling pathway | 0.001 | PDGFRB;NGFR;TGFB2;FLT1;ANGPT2;CSF1;DUSP1;HGF;IGF2;HSPB1;ELK1;PGF;TGFBR2;GNA12; EPHA2;HSPA1A |
| Hippo signaling pathway | 0.01 | YAP1;CRB2;WWTR1;TGFB2;LATS2;CCN2;BMP6;TEAD2;GLI2;TGFBR2 |
| Pathways in cancer | 0.02 | PDGFRB;NOTCH2;CDKN1A;CDKN2B;TGFB2;LAMB2;HGF;MMP2;FN1;IGF2;LRP5;CXCR4;ELK1; PGF;GLI2;TGFBR2;NFKBIA;CASP7;SMO;GNA12 |
| Ras signaling pathway | 0.02 | PDGFRB;NGFR;FLT1;ANGPT2;CSF1;HGF;IGF2;FOXO4;ELK1;PGF;EPHA2;PLA1A |
| TGF-beta signaling pathway | 0.02 | TGFB2;CDKN2B;ID3;DCN;BMP6;RGMA;TGFBR2 |
| Regulation of actin cytoskeleton | 0.02 | VAV3;PDGFRB;ITGB5;ITGA10;GNA12;FN1;CXCR4;ITGB8;IQGAP1;ITGA5;EZR |
| 4 more.. | ||
| Male Downregulated Genes (n = 98) | ||
| Malaria | 0.02 | HBB;HBA2;HBA1 |
| Neuroactive ligand-receptor interaction | 0.02 | MAS1;ADCYAP1;SST;TAC3;TAC1;VIP |
| Taurine and hypotaurine metabolism | 0.02 | GAD1;GAD2 |
| African trypanosomiasis | 0.03 | HBB;HBA2;HBA1 |