Table 2.

Sex-adjusted regression models of the association of childhood social class (age 4) and adult social class (age 53), respectively, with four DNA methylation AA markers measured at age 53 in men and women (n=1273)

	Horvath AA	Hannum AA	PhenoAge AA	GrimAge AA
	Coeff. (95% CI)	Coeff. (95% CI)	Coeff. (95% CI)	Coeff. (95% CI)
Childhood social class
Professional	Reference	Reference	Reference	Reference
Intermediate	1.02 (−0.05 to 2.08)	0.61 (−0.48 to 1.71)	1.69 (0.22 to 3.16)	1.26 (−0.02 to 2.54)
Skilled non-manual	0.42 (−0.63 to 1.47)	0.81 (−0.27 to 1.89)	1.83 (0.38 to 3.29)	0.85 (−0.42 to 2.12)
Skilled manual	0.60 (−0.41 to 1.61)	1.27 (0.24 to 2.30)	2.69 (1.30 to 4.07)	2.55 (1.34 to 3.76)
Partly skilled	0.45 (−0.59 to 1.50)	1.34 (0.26 to 2.41)	2.23 (0.78 to 3.67)	2.14 (0.88 to 3.40)
Unskilled	1.00 (−0.33 to 2.33)	2.04 (0.68 to 3.41)	3.59 (1.75 to 5.43)	2.95 (1.35 to 4.56)
P value for trend	0.94	<0.001	<0.001	<0.001*
Adult social class
Professional	Reference	Reference	Reference	Reference
Intermediate	−0.20 (−1.15 to 0.74)	0.43 (−0.54 to 1.40)	0.41 (−0.91 to 1.72)	0.89 (−0.24 to 2.03)
Skilled non-manual	0.06 (−0.96 to 1.07)	0.91 (−0.14 to 1.95)	1.13 (−0.28 to 2.54)	1.45 (0.23 to 2.67)
Skilled manual	0.84 (−0.18 to 1.86)	1.28 (0.23 to 2.33)	1.18 (−0.24 to 2.60)	3.01 (1.78 to 4.24)
Partly skilled	−0.33 (−1.42 to 0.77)	−0.11 (−1.23 to 1.02)	1.12 (−0.40 to 2.64)	2.16 (0.84 to 3.47)
Unskilled	−0.52 (−1.91 to 0.87)	0.58 (−0.85 to 2.00)	2.25 (0.32 to 4.18)	3.70 (2.04 to 5.37)
P value for trend	0.04*	0.01*	0.01	<0.001*

*Test for heterogeneity across groups if evidence of deviation from linearity.

AA, age acceleration.