Table 3.

Sex-adjusted regression models of the association of intergenerational social class change (between age 4 and age 53) with four DNA methylation AA markers measured at age 53 in men and women (n=1273)

	Horvath AA	Hannum AA	PhenoAge AA	GrimAge AA
	Coeff. (95% CI)	Coeff. (95% CI)	Coeff. (95% CI)	Coeff. (95% CI)
Intergenerational social class change
Stable non-manual	Reference	Reference	Reference	Reference
Non-manual to manual	0.76 (−0.11 to 1.64)	0.45 (−0.45 to 1.34)	0.63 (−0.58 to 1.84)	1.74 (0.69 to 2.78)
Manual to non-manual	0.06 (−0.48 to 0.60)	0.98 (0.43 to 1.53)	1.05 (0.30 to 1.79)	1.27 (0.62 to 1.92)
Stable manual	0.19 (−0.40 to 0.77)	0.62 (0.03 to 1.22)	1.39 (0.58 to 2.19)	2.62 (1.92 to 3.32)

AA, age acceleration.