Table 4.

Statistical analysis results (linear model) of the signature metabolites (CP vs control)

Dataset (matrix)	Identification study (plasma)	First validation study (plasma)	Second validation study (serum)	Importance of rank in the algorithm
Metabolite	Fold change (p value)	Fold change (p value)	Fold change (p value)
Beta-carotene	0.37 (6.8x10-8)	0.38 (2.5x10-21)	0.47 (0.00017)	1
Cryptoxanthin	0.40 (8.8x10-8)	0.38 (8.8x10-19)	0.48 (0.00043)	2
Mannose	1.47 (5.9x10-8)	1.52 (3.9x10-29)	2.80 (7.3x10-14)	3
Behenic acid (C22:0)	0.72 (0.00024)	0.67 (4.9x10-17)	1.14 (0.10586)	4
Ceramide (d18:1, C24:1)	1.27 (0.00016)	1.28 (1.3x10-11)	1.96 (6.7x10-13)	5
Indole-3-acetic acid	0.63 (0.00086)	0.62 (4.2x10-9)	1.15 (0.33726)	6
Hippuric acid	0.68 (0.039)	0.49 (2.2x10-8)	0.51 (0.00173)	7
N-acetylcytidine	1.22 (0.0096)	1.21 (2.3x10-5)	2.36 (3.3x10-13)	8

CP, chronic pancreatitis.