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. 2021 Sep 30;11:729756. doi: 10.3389/fcimb.2021.729756

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Copyright © 2021 Guo, Lan, Wen, Zheng, Rong, Liu, Chen, Yang, Zheng and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Comparison of the gut microbiota between EV71, CVA16, and control group. (A–D) Alpha diversity. Comparison of alpha-diversity indices (Shannon, observed ASVs, PD whole tree and Chao 1 index) among EV71-infected HFMD, CVA16-infected HFMD and control groups (Kruskal-Wallis tests). (E) Relative abundance of the bacterial microbiota at the genus level among EV71, CVA16, and control group. (F–H) Beta diversity. Principal coordinate analysis (PCoA) based on the Bray-Curtis distance (F), unweighted UniFrac distances (G) and weighted UniFrac distances (H) revealed that the relationship of bacterial communities among EV71-infected HFMD, CVA16-infected HFMD and control groups. The explanation of diversity captured by the coordinate is given as a percentage.