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. 2021 Sep 30;12:760747. doi: 10.3389/fimmu.2021.760747

Figure 5.

Figure 5

IGF2BP2 involved in the immune response of monocytes in peripheral blood of CRC patients. (A) EnrichmentMap pathways network revealed overlaps among IGF2BP2 high-expressed phenotype enriched pathways relating to immunity in peripheral blood of CRC patients. Nodes are colored by Enrichment Score, and edges are sized on the basis of the number of genes shared by the connected pathways. (B) GSEA indicated that IGF2BP2 was negatively correlated with the immune response of monocytes. (C) GSEA indicated that IGF2BP2 was positively correlated with monocyte chemotaxis and cytokine production. (D) Leading edge analysis of their intersection genes indicates the vital genes shared by the IGF2BP2 high-expressed phenotype associated with the immune response of monocytes. (E) STRING database analysis revealed that IGF2BP2 interacted with the above vital genes related to the immune response of monocytes.