Figure 8.

Self-assembly schematics of GD2-aptamer-mediated nanostructure for targeting transportation of chemotherapeutics and gene therapy in NB theranostic applications

(A) Self-construction of ANM from ssDNA. (B) Specific recognition of ANM to GD2⁺ cells. (C) Targeted drug delivery of ANM to GD2⁺ cells: (1, ANM first bind with GD2⁺ cells specially via the binding specificity of GD2 aptamer to GD2 molecule; 2, ANM was transferred by endocytic/lysosome vacuole; 3, ANM was degraded, chemotherapeutics Dox and siRNA were released; and 4, Dox and siRNA were released, further inducing cell death and gene silencing).