Table 1.

Abridged list of microbial receptors for complement regulatory proteins and their ligands.

Pathogen	Host Target	Pathogenic Component	References
Aspergillus fumigatus	Factor H	AfEno1	(Vogl et al., 2008; Dasari et al., 2019)
	C4bp	AfEno1	(Vogl et al., 2008; Dasari et al., 2019)
	Plasminogen	AfEno1	(Dasari et al., 2019)
Bordetella pertussis	Factor H	unknown receptor	(Amdahl et al., 2011)
	C4bp	filamentous hemagglutinin	(Berggard et al., 1997)
	C1-inh	Vag8	(Marr et al., 2007; Marr et al., 2011)
Borrelia spp.	Factor H	CRASPs; Erp-family proteins	(Brissette et al., 2009; Lin et al., 2020)
	C4bp	unidentified 43kD protein	(Pietikainen et al., 2010)
	C1-inh	CihC	(Grosskinsky et al., 2010)
	Plasminogen	CRASPs; Erp-family proteins	(Brissette et al., 2009; Hallstrom et al., 2010; Lin et al., 2020; Schmidt et al., 2021)
Candida albicans	Factor H	Gpm1	(Meri et al., 2002; Poltermann et al., 2007)
	C4bp	Gpm1	(Meri et al., 2004)
	Plasminogen	Gpm1	(Poltermann et al., 2007)
	Vitronectin	Gpm1	(Poltermann et al., 2007; Lopez et al., 2014)
Dengue Virus	C4bp	NS1	(Avirutnan et al., 2010; Avirutnan et al., 2011)
	Vitronectin	NS1	(Conde et al., 2016)
Escherichia coli	C4bp	OmpA	(Prasadarao et al., 2002)
	C1-inh	StcE	(Lathem et al., 2004)
Haemophilus influenzae	Factor H	Protein H, P5	(Hallstrom et al., 2008; Fleury et al., 2014; Rosadini et al., 2014; Langereis et al., 2014)
	C4bp	unknown receptor	(Hallstrom et al., 2007)
	Plasminogen	Protein E	(Barthel et al., 2012)
	Vitronectin	Haemophilus surface fibrils; Protein E; Protein F; Protein H; P4	(Hallstrom et al., 2006; Singh et al., 2011; Su et al., 2013a; Al-Jubair et al., 2015; Su et al., 2016)
Human Immunodeficiency Virus (HIV)	Factor H	gp120; gp41	(Stoiber et al., 1995a; Stoiber et al., 1995b; Stoiber et al., 1996)
	C4bp	gp120	(Stoiber et al., 1995b)
Leptospira spp.	Factor H	Enolase	(Meri et al., 2005; Salazar et al., 2017)
	C4bp	Enolase	(Barbosa et al., 2009; Salazar et al., 2017)
Moraxella catarrhalis	Factor H	OlpA	(Bernhard et al., 2014)
	C4bp	UspA	(Nordstrom et al., 2004)
	Plasminogen	UspA	(Singh et al., 2015)
	Vitronectin	UspA	(Su et al., 2013b)
Neisseria gonorrhoeae	Factor H	Por1B, LOS	(Ram et al., 1998; Madico et al., 2007)
	C4bp	Por1A	(Ram et al., 2001a; Ram et al., 2001b)
Neisseria meningitidis	Factor H	fHbp	(Madico et al., 2006)
	C4bp	PorA	(Jarva et al., 2005)
	Vitronectin	OpcA; Msf	(Griffiths et al., 2011; Hubert et al., 2012)
Streptococcus pneumoniae	Factor H	PspC	(Dave et al., 2001)
	C4b	PspA; PspC; LytA; PepO	(Dieudonne-Vatran et al., 2009; Agarwal et al., 2012; Ramos-Sevillano et al., 2015; Haleem et al., 2019)
	Plasminogen	PepO	(Agarwal et al., 2013)
	Vitronectin	Hic	(Kohler et al., 2015)
Streptococcus pyogenes	Factor H	M Protein	(Peterson et al., 1979; Horstmann et al., 1988)
	C4bp	M Protein	(Thern et al., 1995)
	Vitronectin	Streptokinase	(Ullberg et al., 1989)
West Nile Virus	Factor H	NS1	(Chung et al., 2006)
	C4bp	NS1	(Avirutnan et al., 2010; Avirutnan et al., 2011)
Yellow Fever Virus	C4bp	NS1	(Avirutnan et al., 2010; Avirutnan et al., 2011)
Yersinia spp.	Factor H	YadA; Ail	(Biedzka-Sarek et al., 2008)
	C4bp	YadA; Ail	(Kirjavainen et al., 2008)
	Vitronectin	Ail	(Thomson et al., 2019)