Figure 3.

Predicted pathways (based on 16S rRNA gene sequences) that displayed a significantly (LEfSe) higher relative abundances in OVX-E2-High rats than in OVX-Vehicle rats. Relative abundance of polyamine biosynthesis and sucrose degradation represents the sum of the predicted relative abundance of arginine and polyamine biosynthesis and polyamine biosynthesis I and sucrose degradation III and IV, respectively ( Supplemental Figure S9 ). Urea cycle: PWY-4984. The asterisks indicate significant differences (*p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001). Solid lines between groups indicate significant q values (q ≤ 0.05). Dashed lines between groups indicate non-significant q values. Group abbreviations (e.g., Sham-Vehicle) are described in Table 1 . Error bars indicate standard deviations.