Table 1.

Distribution of mGluR in CNS.

Group	Receptor	CNS distribution	References
Group I	mGluR1	Widespread in neurons (cerebellar olfactory tubercle, cerebral cortex, dentate gyrus, lateral septal nucleus, striatum, nucleus accumbens, amygdaloid nuclei, substantia nigra pars reticulata and cerebellar cortex)	Pin and Duvoisin, 1995; Kniazeff et al., 2011; Ribeiro et al., 2011
	mGluR5	Widespread in neurons (cerebral, cortex, Hippocampus, subiculum, olfactory bulb, striatum nucleus accumbens lateral septal nucleus)	Abe et al., 1992; Shigemoto et al., 1993; Romano et al., 1995
		Astrocytes	Biber et al., 2010; Schools and Kimelberg, 2015
Group II	mGluR2	Widespread in neurons (cerebellar cortex and olfactory bulb)	Ohishi et al., 1993, 1994
	mGluR3	Widespread in neurons (cerebellar olfactory tubercle, cerebral cortex, dentate gyrus, lateral septal nucleus, striatum, nucleus accumbens, amygdaloid nuclei, substantia nigra pars reticulata and cerebellar cortex)	Tanabe et al., 1993; Testa et al., 1994; Petralia et al., 1996; Ohishi et al., 2010
		Astrocyte	Tanabe et al., 1993; Ohishi et al., 1994, 2010
Group III	mGluR4	most intense in the cerebellum	Fotuhi et al., 1994; Kinoshita et al., 1996; Makoff et al., 1996; Azkue et al., 2015
	mGluR6	Retina	Nakajima et al., 1993
	mGluR7	Widespread in neurons	Kinoshita et al., 2015
	mGluR8	Lower and more restricted than mGluR4/7	Duvoisin et al., 1995; Saugstad et al., 1997; Corti et al., 1998