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. 2021 Sep 30;12:743202. doi: 10.3389/fendo.2021.743202

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Copyright © 2021 Xie, Chen, Xu, Li, Ni, Hou, Chen, Chang, Yang, Wang, He, Chen, Qian, Luo, Zhang, Li, Zhu, Ji and Liu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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GGA improved insulin resistance and glucose intolerance in MAFLD mice. (A) Blood glucose at each time point during ip. GTT, *CON-NS vs. NASH-NS, ^#NASH-NS vs. NASH-GGA. (B) Area under the curve of glucose for ip. GTT. (C) Blood glucose at each time point during ip. ITT, *CON-NS vs. NASH-NS, ^#NASH-NS vs. NASH-GGA. (D) Area under the curve of glucose for ip. ITT. (E) Comparison of fasting serum insulin levels between the groups. (F) Comparison of lipid profile in each group. Data are presented as mean ± SEM. The significance among the groups was determined using the two-way ANOVA with LSD’s multiple comparisons test (n = 4 in CON-NS group, n = 6 in CON-GGA group, n = 7 in NASH-NS group, n = 7 in NASH-GGA group), *^,# p < 0.05, **^,## p < 0.01, ***^,### p < 0.001.