TABLE 1.
Baseline demographic and clinical characteristics by cognitive group status
| Total Sample N = 947 | CU N = 402 | Obj‐SCD N = 199 | MCI N = 346 | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean or % | SD or N | Range | Mean or % | SD or N | Range | Mean or % | SD or N | Range | Mean or % | SD or N | Range | F or χ2 | P | |
| Age | 73.60 | 7.43 | 55.00–93.60 | 73.40 | 7.30 | 55.00–91.40 | 73.87 | 7.43 | 55.00–90.40 | 73.68 | 7.60 | 55.00–93.60 | F = 0.29 | .747 |
| Education | 16.26 | 2.69 | 6–20 | 16.45 | 2.69 | 6–20 | 16.26 | 2.53 | 10–20 | 16.05 | 2.78 | 7–20 | F = 1.99 | .137 |
| Female/woman, % | 47.2% | N = 447 | 51.5% | N = 207 | 43.2% | N = 86 | 44.5% | N = 154 | χ2 = 5.25 | .073 | ||||
| Race | χ2 = 21.49 | .044 | ||||||||||||
|
American Indian/Alaska Native |
0.2% | N = 2 | 0.5% | N = 2 | 0.0% | N = 0 | 0.0% | N = 0 | ||||||
| Asian | 1.4% | N = 13 | 1.0% | N = 4 | 2.5% | N = 5 | 1.2% | N = 4 | ||||||
| Black | 4.0% | N = 38 | 2.5% | N = 10 | 5.0% | N = 10 | 5.2% | N = 18 | ||||||
|
Hawaiian/Pacific Islander |
0.2% | N = 2 | 0.0% | N = 0 | 0.0% | N = 0 | 0.6% | N = 2 | ||||||
| White | 92.6% | N = 877 | 94.5% | N = 380 | 92.5% | N = 184 | 90.5% | N = 313 | ||||||
| More than one | 1.3% | N = 12 | 1.5% | N = 6 | 0.0% | N = 0 | 1.7% | N = 6 | ||||||
| Unknown | 0.3% | N = 3 | 0.0% | N = 0 | 0.0% | N = 0 | 0.9% | N = 3 | ||||||
| Ethnicity | χ2 = 2.35 | .672 | ||||||||||||
| Hispanic | 3.5% | N = 33 | 2.7% | N = 11 | 3.0% | N = 6 | 4.6% | N = 16 | ||||||
| Non‐Hispanic | 96.1% | N = 910 | 96.8% | N = 389 | 96.5% | N = 192 | 95.1% | N = 329 | ||||||
| Unknown | 0.4% | N = 4 | 0.5% | N = 2 | 0.5% | N = 1 | 0.3% | N = 1 | ||||||
| MMSE | 28.46 | 1.69 | 23–30 | 28.98 | 1.44 | 24–30 | 28.47 | 1.57 | 24–30 | 27.84 | 1.82 | 21–30 | F = 46.07 [Link] , b , c | <.001 |
| Pulse pressure | 59.49 | 15.38 | 59.54 | 16.04 | 60.58 | 14.15 | 58.80 | 15.28 | F = 0.85 | .427 | ||||
| APOE ε4 frequency | χ2 = 43.79 b , c | <.001 | ||||||||||||
| 0 ε4 alleles | 61.6% | N = 583 | 70.1% | N = 282 | 65.3% | N = 130 | 49.4% | N = 171 | ||||||
| 1 ε4 allele | 32.6% | N = 309 | 27.1% | N = 109 | 30.7% | N = 61 | 40.2% | N = 139 | ||||||
| 2 ε4 alleles | 5.8% | N = 55 | 2.7% | N = 11 | 4.0% | N = 8 | 10.4% | N = 36 | ||||||
| Aβ‐PET SUVR* | 1.17 | 0.21 | 0.84–2.03 | 1.12 | 0.18 | 0.84–2.03 | 1.16 | 0.20 | 0.84–1.84 | 1.25 | 0.24 | 0.84–2.00 | F = 31.92 [Link] , b , c | <.001 |
| Plasma p‐tau181 (pg/mL) | 16.92 | 10.41 | 0.36–72.26 | 15.56 | 10.19 | 0.36–72.26 | 15.07 | 8.91 | 0.83–50.40 | 19.56 | 10.95 | 2.06–69.60 | F = 21.96 b , c | <.001 |
| PACC | −3.05 | 4.68 | −16.90–6.26 | −0.58 | 3.58 | −13.31–5.48 | −2.73 | 3.80 | −16.90–4.64 | −6.12 | 4.51 | −16.90–6.26 | F = 179.95 [Link] , b , c | <.001 |
| FAQ | 1.73 | 3.31 | 0–22 | 0.80 | 2.27 | 0–18 | 1.55 | 2.82 | 0–13 | 2.94 | 4.12 | 0–22 | F = 42.80 [Link] , b , c | <.001 |
| CDR‐SB | 0.91 | 1.10 | 0–5.5 | 0.51 | 0.93 | 0–3.5 | 0.86 | 1.08 | 0–3.5 | 1.40 | 1.11 | 0–5.5 | F = 69.77 [Link] , b , c | <.001 |
Note: F statistic reported for one‐way ANOVAs, χ2 statistic reported for chi‐square tests.
significant differences between CU and Obj‐SCD.
significant differences between CU and MCI.
significant difference between Obj‐SCD and MCI.
subset of participants (Total N = 824; CU n = 348; Obj‐SCD n = 177; MCI n = 299) had Aβ‐PET.
Abbreviations: CU, Cognitively normal; Obj‐SCD, Objectively‐defined subtle cognitive decline; MCI, mild cognitive impairment; MMSE, Mini‐Mental State Examination; APOE, apolipoprotein E; Aβ, amyloid beta; SUVR, standardized uptake value ratio; PACC, modified Preclinical Alzheimer Cognitive Composite; FAQ, Functional Activities Questionnaire; CDR‐SB, Clinical Dementia Rating–Sum of Boxes.