Fig. 6.

Levels of oxidative stress and expression of NASH-related genes are unchanged in male Mttp-IKO mice following switch from HFFC to chow diet. A: Liver TBARS content, n = 4–5/group, with levels in MCD-fed control mice shown for comparison. B: Serum ALT, n = 9–10/group. C: Serum FITC-dextran FD4 levels 2 h after oral gavage, n = 5–7/group. D: mRNA expression of genes related to fibrosis, inflammation, and lipogenesis (n = 6/genotype). E: Expression of total and phosphorylated JNK and NF-κB proteins. A representative immunoblot and quantitation of relative protein expression levels are shown (n = 5/group). Abbreviations are as outlined in the legend to Fig. 5. For all panels, ∗P < 0.05 and ∗∗P < 0.01.