Fig. 7.

Correlation between hepatic TG content and fibrotic area. A: A positive association between hepatic TG content and fibrotic area in male Mttp-IKO mice-fed MCD diet for 3 weeks. B: No correlation between hepatic TG content and fibrotic area in the MCD reversal experiments, including data from male and female mice ± Mttp deletion with continued MCD feeding (control, Mttp-IKO) and mice ± Mttp deletion concomitant with switch to chow diet (→chow, →IKO chow). C: No correlation between hepatic TG content and fibrotic area in the HFFC reversal experiments. Groups include male mice-fed HFFC for 14 weeks, mice fed HFFC for 10 weeks, chow for 4 weeks (HFFC → chow), and mice fed HFFC for 10 weeks, chow for 4 weeks with intestinal Mttp deletion (HFFC → IKO chow). Pearson correlation coefficient (Pearson's r) and P values are shown on each graph.