Table 4. Primary Analyses:

Association between MIND Diet Score and MRI measures in RADIEMS Cohort of People with Early MS

			Thalamic Volume*	Lesion volume*	NAWM FA MD*	Gray matter volume*
Diet quality score	Quartile	Mean (SD)	Beta** (95% CI)	Beta** (95% CI)	Beta** (95% CI)	Beta** (95% CI)
MIND	Q1	6.47 (1.03)	0.00 [ref]	0.00 [ref]	0.00 [ref]	0.00 [ref]
	Q2	8.29 (0.25)	0.62 (-0.08, 1.33)	-0.32 (-0.87, 0.23)	0.52 (0.15, 0.89)	4.46 (-12.66, 21.58)
	Q3	9.28 (0.25)	1.16 (0.41, 1.91)	-0.29 (-0.88, 0.30)	0.36 (-0.04, 0.76)	14.75 (-3.41, 32.90)
	Q4	10.68 (0.81)	1.03 (0.26, 1.79)	-0.11 (-0.72, 0.49)	0.40 (-0.00, 0.80)	7.17 (-11.43, 25.78)
	P for linear trend across quartiles		0.002	0.65	0.08	0.24

^*Units for volumetric measures are presented as mL. T2 lesion volume was log-transformed to improve normality; NAWM FA MD: Normal appearing white matter fractional anisotropy, mean diffusivity.

^**Adjusted for age, sex, race, ethnicity, socio-economic status, physical activity, BMI, smoking status, disease duration, disease modifying therapy use and class, and total energy intake.