Table 6:
Types of dietary fat and adjusted mean difference* in MRI measures
| Thalamic Volume | Lesion volume | NAWM FA MD** | Gray matter volume** | |||
|---|---|---|---|---|---|---|
| Quartile | Mean (SD) | Beta* (95% CI) | Beta* (95% CI) | Beta* (95% CI) | Beta* (95% CI) | |
| Saturated fat, grams per day | Q1 | 18.22 (3.12) | −63.44 (−797.03, 670.15) | 0.19 (−0.36, 0.74) | −0.28 (−0.65, 0.10) | 0.22 (−16.83, 17.28) |
| Q2 | 22.52 (0.75) | −73.99 (−829.75, 681.77) | 0.13 (−0.43, 0.70) | −0.35 (−0.73, 0.04) | −10.92 (−28.49, 6.65) | |
| Q3 | 25.23 (0.93) | −101.62 (−852.52, 649.28) |
−0.03 (−0.59, 0.53) | −0.20 (−0.58, 0.18) | −0.88 (−18.34, 16.58) | |
| Q4 | 30.31 (3.55) | −63.44 (−797.03, 670.15) | 0.19 (−0.36, 0.74) | −0.28 (−0.65, 0.10) | 0.22 (−16.83, 17.28) | |
| P for Trend | 0.80 | 0.85 | 0.34 | 0.73 | ||
| Polyunsaturated fat, grams per day | Q1 | 12.31 (1.41) | 0.00 [ref] | 0.00 [ref] | 0.00 [ref] | |
| Q2 | 15.14 (0.59) | 169.95 (−602.92, 942.81) | 0.16 (−0.41, 0.73) | −0.06 (−0.45, 0.34) | 0.02 (−17.96, 18.01) | |
| Q3 | 16.70 (0.42) | −76.57 (−824.34, 671.20) | 0.62 (0.07, 1.18) | −0.33 (−0.70, 0.05) | −3.24 (−20.65, 14.16) | |
| Q4 | 21.62 (7.25) | 216.54 (−527.66, 960.74) | 0.54 (−0.01, 1.09) | 0.01 (−0.37, 0.39) | −12.10 (−29.42, 5.22) | |
| P for Trend | 0.70 | 0.02 | 0.80 | 0.14 | ||
| Omega-3 polyunsaturated fats, milligrams per day | Q1 | 1.44 (0.20) | 0.00 [ref] | 0.00 [ref] | 0.00 [ref] | |
| Q2 | 1.84 (0.09) | 116.72 (−632.19, 865.63) | 0.33 (−0.23, 0.89) | −0.07 (−0.45, 0.32) | 1.44 (−16.05, 18.94) | |
| Q3 | 2.18 (0.10) | −68.73 (−832.11, 694.65) | 0.29 (−0.29, 0.86) | −0.00 (−0.39, 0.39) | −4.34 (−22.17, 13.50) | |
| Q4 | 3.24 (1.26) | 311.12 (−441.73, 1063.97) | 0.07 (−0.50, 0.63) | 0.14 (−0.25, 0.52) | −9.22 (−26.80, 8.37) | |
| P for Trend | 0.44 | 0.92 | 0.37 | 0.21 | ||
| Alpha-linolenic acid, milligrams per day | Q1 | 1.13 (0.26) | 0.00 [ref] | 0.00 [ref] | 0.00 [ref] | |
| Q2 | 1.49 (0.07) | −227.17 (−991.68, 537.34) | 0.12 (−0.45, 0.70) | 0.11 (−0.29, 0.50) | 2.66 (−15.21, 20.53) | |
| Q3 | 1.73 (0.07) | 150.07 (−637.52, 937.66) | 0.11 (−0.48, 0.70) | 0.11 (−0.30, 0.52) | −0.97 (−19.38, 17.44) | |
| Q4 | 2.59 (1.19) | −388.39 (−1127.09, 350.32) | 0.45 (−0.11, 1.00) | −0.06 (−0.44, 0.32) | −11.01 (−28.28, 6.26) | |
| P for Trend | 0.39 | 0.11 | 0.65 | 0.15 | ||
| Marine n-3 fatty acids, milligrams per day | Q1 | 0.08 (0.08) | 0.00 [ref] | 0.00 [ref] | 0.00 [ref] | |
| Q2 | 0.25 (0.03) | 302.55 (−416.76, 1021.87) | −0.09 (−0.63, 0.45) | 0.15 (−0.21, 0.51) | 5.35 (−11.37, 22.07) | |
| Q3 | 0.42 (0.08) | 560.17 (−159.92, 1280.26) | −0.23 (−0.77, 0.32) | 0.49 (0.12, 0.85) | 17.47 (0.73, 34.21) | |
| Q4 | 1.00 (0.29) | 371.14 (−350.09, 1092.37) | −0.45 (−0.99, 0.09) | 0.40 (0.03, 0.76) | 3.50 (−13.27, 20.26) | |
| P for Trend | 0.42 | 0.09 | 0.04 | 0.86 |
*
Adjusted for age, sex, race, ethnicity, socio-economic status, physical activity, BMI, smoking status, disease duration, disease modifying therapy use and class, and total energy intake.