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. 2021 Oct 13;5(1):e001206. doi: 10.1136/bmjpo-2021-001206

Table 1.

Eligible studies

Paper The study Leukotriene receptor antagonist Other drugs
First author Year Type of study Patients (of relevant age) Patients administered the LTRA Age of patients Participant characteristics (as presented in study) LTRA administered Dose information given Length of drug administration prior to ADR presentation Additional drugs administered by patients
Lenney 26 2013 Randomised, double-blind, placebo controlled, parallel study 63 21 6–14 years 11 months 40 males, 23 females (whole study) Montelukast 5 mg/day 0–48 weeks Inhaled fluticasone propionate 100 µg two times per day.
Ammari 29 2018 Prospective cohort study 56 56 2–17 years Not specified Montelukast Not specified 1–24 weeks Inhaled steroids.
Ghosh 27 2006 Prospective cohort study 50 50 3–11 years 28 males, 22 females Montelukast 3–4 years 4 mg,
>4 years 5 mg		 Not specified Salbutamol or terbutaline, used when needed.
Kukreja 28 2004 Prospective cohort study 881 881 6–14 years 573 males, 308 females Montelukast 5 mg/day 0–30 days Short acting inhaled beta-2-agonists, used ‘as needed’.
Arnold 45 2020 Retrospective cohort study 312 312 age 6 (5–8) years (median (IQR)) 55% male, 45% female Montelukast (0.5–17.8 mg/kg/day) Not specified Not specified.
Benard 46 2017 Retrospective cohort study 223 106 1–17 years 66 male, 40 female (case).
66 Caucasian, 21 North African, 4 black, 3 Asian, 3 East Indian, 3 Hispanic,
6 inter-racial/other (case).		 Montelukast 2 unknown,
53 4 mg/day,
47 5 mg/day,
4 10 mg/day		 Not specified Not specified.
Erdem 47 2015 Retrospective cohort study 1024 1024 Not specified (‘children’) Not specified Not specified Not specified Not specified Not specified.
Glocker-Lauf 48 2018 Matched, nested case–control study 4395 4395 5–18 years 1874/3497 female (control), 476/898 female (case). Montelukast Not specified Not specified ‘Asthma Maintenance Medication’ other than an LTRA.
Kobayashi 31 2003 Case report 1 1 17 years Japanese male Pranlukast 450 mg/day 13 months Theophylline 400 mg/day.
Kocyigit 49 2013 Case report 1 1 13 years Male Montelukast Not specified 24–36 hours Salbutamol, formoterol and budesonide.
Byrne 50 2012 Case report 1 1 9 years Caucasian male Montelukast 5 mg/day 2.5 years Beclomethasone inhaler, 50 mcg, 1 puff two times per day.
Montoro De Francisco 30 2015 Case report 1 1 7 years Male Montelukast 4 mg/day 12 hours Not specified.
Scholz 51 2019 Case report 1 1 11 years Male Montelukast Not specified 4 months Salbutamol and salmeterol/fluticasone.
Skillman 52 2011 Case report 2 2

  1. 4 years

  2. 6 years

  1. Male

  2. Hispanic female

 Montelukast

  1. 5 mg/day

  2. 4 mg/day then 5 mg/day

  1. Since starting

  2. Since does increase after child’s sixth birthday

  1. Albuterol 2.5 mg nebulised every 4–6 hours, cetirizine 5 mg daily.

  2. Fluticasone oral inhaler 44 mcg two times per day, cetirizine 5 mg.
Star 53 2011 Case report 1 1 Teenage Male Montelukast Not specified Not specified Escitalopram which was later changed to venlafaxine and risperidone.

ADR, adverse drug reaction; LTRA, leukotriene receptor antagonist.