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. 2021 Sep 24;22(6):1358. doi: 10.3892/etm.2021.10793

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Copyright: © Luo et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Knockdown of CMPK2 decreases IL-18 and IL-1β by inhibiting the NLRP3 inflammasome, and not AIM2. Protein detection of (A) NLRP3 or (B) AIM2 following H/R treatment in scramble siRNA or specific siRNA-transfected RAW 264.7 cells. (C) Protein detection and respective quantification of (D) cleaved-caspase-1, (E) IL-18 and (F) IL-1β in the H/R + CMPK2 siRNA, H/R + CMPK2 siRNA + NLRP3 siRNA, and H/R + CMPK2 siRNA + AIM2 siRNA groups. ^##P<0.01 vs. H/R +CMPK2 siRNA group. CMPK2, cytidine monophosphate kinase 2; NLRP3, NLR family pyrin domain containing 3; H/R, hypoxia/reoxygenation; AIM2, absent in melanoma 2; siRNA, small interfering RNA.