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. 2021 Oct 12;218(12):e20211427. doi: 10.1084/jem.20211427

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© 2021 Huang et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 1. — Integrative analysis of latent reservoirs in ART-treated participants. (A) Experimental design. Env sequences from inducible proviruses are obtained by limiting dilution viral outgrowth cultures (Lorenzi et al., 2016), and NFL sequences are obtained by Q4PCR (Gaebler et al., 2019). Paired NFL sequencing and integration site mapping is performed by modified MIP-seq (Einkauf et al., 2019). (B) Pie chart summarizes the total number of intact and defective proviral sequences mapped, center. Intact proviruses in blue, and defective in gray. (C) Pie chart shows the proportion of intact proviruses that are inducible in vitro in white. Intact proviruses not detected by quantitative and qualitative viral outgrowth assay (Q2VOA) represented in blue. The number in center indicates the total number of intact proviral integrations mapped.