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. 2021 Oct 12;153(12):e202112969. doi: 10.1085/jgp.202112969

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© 2021 Eldstrom et al.

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Figure 5. — Increased single-channel current amplitudes in R2 and R4 mutants with ML277. (A and B) Representative single-channel recordings of R2 in control (A) and in 1 µM ML277 (B) from the same patch. The voltage protocol is shown above the control sweeps, and the interpulse interval was 10 s. (C) All-points histograms of 10 R2 single-channel recording sweeps in control (blue) and 10 sweeps in 1 µM ML277 (red) from the same patch. All-points histograms of R4 single-channel sweeps (right). (D) Representative sweeps of single-channel recordings of R4 in control conditions (upper sweep) and in 1 µM ML277 (lower sweep) from the same patch. The voltage protocol is shown above the control sweeps, and the interpulse interval was 10 s. (E) Amplitudes of openings for R2, R4, and KCNQ1 after exposure to ML277 as determined by Gaussian fits of all-points histograms. Error bars denote mean ± SEM.