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. 2021 Oct 14;16:431. doi: 10.1186/s13023-021-02034-6

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Radiographic imaging of skeletal manifestations in Gaucher disease. Generalized osteopaenia and lytic areas in iliac wings (A) and mid shafts of both femora (A, B), tibiae (B) and humeri (C). Pathological fractures both upper femora (A). Erlenmeyer flask deformity of both femurs, also known as metaphyseal flaring (B). Gross expansion and coarse trabeculation of the left femur (D). Extensive osteonecrosis of the right femoral head, which shows marked flattening with complete loss of joint space (E). Prominent thoracic kyphosis and exaggerated lumbar lordosis with minimal lumbar curve (F). H-shaped vertebrae of the thoracic spine consistent with osteonecrosis (G)