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Cumulative hazard for first osteonecrosis event and fragility fracture. Controlling for gender, the hazard or risk of having a first osteonecrosis event (A) and first fragility fracture (B) after presentation of Gaucher disease was greater in patients who had splenectomy (hazard ratio of 3.32 [95% CI 1.74–5.00; p < 0.001] and 2.83 [95% CI 1.33–5.99; p = 0.01], respectively). Horizontal axis shows years after presentation with Gaucher disease
