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. 2021 Sep 30;11:669731. doi: 10.3389/fonc.2021.669731

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Copyright © 2021 Zheng, Wang, Liu, Xie, Ge, Yu and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The METTL3/PTTG3P/YAP1 axis is vital for CRC progression (A) CCK8 assay detected the proliferation of HCT-116 cells transfected with sh-PTTG3P or sh-PTTG3P+METTL3. (B) CCK8 assay detected the proliferation of HT29 cells transfected with PTTG3P or PTTG3P+sh-YAP1. (C) CCK8 assay detected the proliferation of HCT-116 cells transfected with METTL3 or METTL3sh-YAP1. (D) Kaplan-Meier analysis of the OS curves for patients with METTL3/PTTG3P-high (both levels of METTL3/PTTG3P were high), METTL3/PTTG3P-low (both levels of METTL3/PTTG3P were low) expression. (E) Kaplan-Meier analysis of the OS curves for patients with PTTG3P/YAP1-high (both levels of PTTG3P/YAP1 were high), PTTG3P/YAP1-low (both levels of PTTG3P/YAP1 were low) expression. Data are presented as the mean ± SD from three independent experiments. *p < 0.05, **p < 0.01.