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. 2021 Jan 7;102(3):001547. doi: 10.1099/jgv.0.001547

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© 2021 The Authors

This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.

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Fig. 4. — Enhanced complement activity in sera without complement-mediated pathology in the kidney in AG129 mice DENV-infected +/-ADE. (a) Serum was subjected to reducing SDS-PAGE and Western blot for C3, with detected of complexes by chemiluminescence and ChemiDOC imaging. Molecular weight markers and presumptive C3 products are indicated. ui naïve (n=2); DENV naïve (n=5), ui immune (n=3); DENV immune (n=5). (b) Results were quantitated using ImageJ and C3 β-chain normalized against total protein determined by stain-free gel imaging. *P<0.05, one-way ANOVA/Tukey’s test; (c) kidneys were fixed, embedded, sectioned and subjected to haematoxylin and eosin staining. Representative images from each group are shown, highlighting normal morphology of glomeruli and tubules.