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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: FEBS Lett. 2021 Sep 29;595(19):2413–2436. doi: 10.1002/1873-3468.14192

Figure 3: The skin is a multi-layer, compartmentalized organ.

Figure 3:

(A) There are three main layers in the skin: epidermis, dermis and hypodermis. Each layer contains multiple cell types. (B) The interfollicular epidermis contains mostly keratinocytes organized into four layers based on differentiation status. The epidermal stem cells reside in the stratum basale. (C) The anagen hair follicle. The matrix contains proliferating keratinocytes derived from the secondary hair germ, giving rise to the hair shaft. (D) The telogen hair follicle. The hair follicle bulge contains the slow cycling stem cells. The hair germ contains the progenitor cells for the hair. The dermal papilla is a mesenchymal structure that signals to the hair germ and stem cells.