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. 2021 Oct 13;9(2):e01352-21. doi: 10.1128/Spectrum.01352-21

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© Crown copyright 2021.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 3 — The protection efficiency of the neutralizing antibody nCoV617 in the ACE2-HU mouse model postinfection with SARS-CoV-2 (a Chinese endemic strain). (A) The scheme flowchart of the experiment. (B to D) In the ACE2 humanized mouse model, body weight (B) and virus copies of SARS-CoV-2 in lung (C) and in trachea (D) count in the therapeutic, prophylactic, and irrelevant MAb (Ag005) negative-control groups. (E to G) Hematoxylin-eosin (HE) staining of ACE2-HU mouse lung tissue sections of the negative-control (E), prophylactic (F), and therapeutic (G) groups. Results presented in panels B to D are representatives of three independent biological experiments.