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. 2021 Sep 30;8:659388. doi: 10.3389/fmolb.2021.659388

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Copyright © 2021 Bian, Huang, Yu and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dysregulation of ARSs and AIMPs in lung cancer. IARS2 regulates lung cancer cell proliferation by activating the AKT/mTOR pathway. AIMP2 interacts with Smurf2 to downregulate c-Myc and sustains TGF-β signaling, thereby inhibiting tumorigenesis. Moreover, AIMP2-DX2 reduces the proapoptotic activity of AIMP2 by competitive binding to p53, which induces lung tumorigenesis. ARSs, aminoacyl-tRNA synthetases; AIMPs, ARS-interacting multifunctional proteins; IARS2, isoleucyl-tRNA synthetase 2; Smurf2, Smad ubiquitination regulatory factors 2; TGF-β, transforming growth factor-β; AIMP2-DX2, AIMP2 lacking exon 2.