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. 2021 Oct 14;17(10):e1009841. doi: 10.1371/journal.ppat.1009841

Fig 4. Requirement for cGAS in controlling viral infection in vivo.

Fig 4

(A) Survival curves of wild-type (n = 13, male = 5, female = 8), MAVS-/- (n = 8, male = 4, female = 4), and cGAS-/- (n = 11, male = 8, female = 3) mice intracerebrally infected with 1.0 × 103 TCID50 of MeV-CAMR. (B, C) wild type or cGAS-/- mice (n = 8, male = 3, female = 5) were intracerebrally inoculated with 1.0 × 103 TCID50 of MeV-CAMR, and the cerebrum was harvested at 5 dpi. (B) mRNA of the MeV-N gene measured by RT-qPCR. (C) IFN-β measured by RT-qPCR, represented as amount measured relative to the amount of MeV-N. Data are representative of three independent experiments. Data are the mean value ± SD (n = 3). Statistical significance was determined by the log rank test (A) or unpaired Student’s t-test (B, C).