Fig 5. Reactivation of eRNAs and TF activities on enhancers.

A: Deconvolved expressions (z-score) of the enhancer regions across the cell-cycle pseudotime. The original expression values have been obtained from Palozola et al. and applied the same deconvolution approach as with promoters (see Fig 1 and Methods). B: Activity of TFs inferred from the deconvolved eRNA expression profiles in A. TFs can be clustered in three groups based on their activities. The first group is active before mitosis (brown), the second one has a minor influence on the mitotic activity and reactivation process (gray), and the latter (orange) is active at the beginning of a new cell cycle. Time units are in minutes.