FIGURE 1.

Construction and proposed mechanism of (DOX+ACE)@ZIF‐8 against the hepatic in‐situ tumor models. A, The preparation of metal‐organic frameworks nanocarrier‐based (DOX+ACE)@ZIF‐8 through one‐pot process. B, High tumor accumulation of (DOX+ACE)@ZIF‐8 through single‐dose percutaneous intratumoral injection under ultrasound guidance, followed by the cellular internalization via endocytosis pathways. At the tumor site, pH‐responsive released ACE inhibits CAIX from catalyzing CO₂ to HCO₃ ⁻ and H⁺ for “desensitizing” the cancer cells to the pH changes, thus enhancing the anticancer activity of DOX