Table 3.
Statistical analyses of for BPD heritability by X2, intra-class correlation and ACE Modeling.BPD heritability by X2, intra-class correlation (ICC) and ACE modeling in twin pairs of primary study, validation and combined cohorts by chorionicity.
| Cohort | Chorionicity | Number in Twin Pairs Affected | ACE modeling Percent of Variability (95% CI) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Neither | One | Both | Total | χ2 | p | ICC (95% CI) | p | %A (Heritability) |
p | %C (Common Environmental) |
p | ||
| Study | MC | 23 | 19 | 16 | 58 | 0.69 | .71 | 0.34 (0.08,0.55) |
.70 | 0.0% (0.0%, 43.1%) |
1.0 | 56.4% (25.0%, 68.0%) |
.004 |
| DC | 88 | 56 | 48 | 192 | 0.39 (0.25,0.51) |
||||||||
| Total | 111 | 75 | 64 | 250 | |||||||||
| Validation | MC | 9 | 7 | 13 | 29 | 2.27 | .32 | 0.51 (0.15,0.75) |
.92 | 6.5% (0.0%, 67.4%) |
.44 | 66.9% (17.2%, 83.7%) |
.016 |
| DC | 34 | 19 | 23 | 76 | .49 (0.27,0.66) |
||||||||
| Total | 43 | 26 | 36 | 105 | |||||||||
| Combined | MC | 32 | 26 | 29 | 87 | 2.33 | .31 | 0.40 (0.20,0.57) |
.88 | 0.0% (0.0%, 38.6%) |
1.0 | 61.2% (33.0%, 70.4%) |
<.001 |
| DC | 122 | 75 | 71 | 268 | 0.42 (0.30,0.52) |
||||||||
| Total | 154 | 101 | 100 | 355 | |||||||||