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. 2021 Oct 15;131(20):e148036. doi: 10.1172/JCI148036

Figure 3. Single-cell RNA-Seq analysis of pulmonary tissues identifies cell population differences between N, MI, and VI animals.

Figure 3

(A) Integrated UMAP (uniform manifold approximation and projection) of all N (n = 4), MI (n = 5), and VI samples (n = 4) excluding one VI outlier sample. (B) Bar plot of cell-type proportions within N (n = 4), MI (n = 5), and VI (n = 4) groups and VI outlier. (C) Box plots comparing cell-type proportions observed in N (n = 4), MI (n = 5), and VI (n = 4) groups excluding one VI outlier. The limits of the box reflect the interquartile range (IQR: Q3–Q1) with median shown as horizontal bars. Whiskers extend to 1.5 times the IQR of the box. Outliers outside 1.5 × IQR are shown as individual points. ANOVA and pairwise comparisons by post hoc Tukey’s test are shown (*P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001). DCα, activated DCs.