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. 2021 Oct 15;131(20):e148036. doi: 10.1172/JCI148036

Figure 9. Network-based functional interpretation of DEGs of MI versus N and VI versus N comparisons in monocytes.

Figure 9

The bubble plot (left) shows key pathways enriched in each functional module (M) within the network plot for DEGs common to both MI versus N and VI versus N comparisons (right) in monocytes. Left: The color of each bubble represents the z score for each pathway, which defines the directional tendency of regulation. A positive z score is represented by red for upregulation, and a negative z score is represented by blue for downregulation. Bubble size corresponds to the proportion of DEGs in each pathway relative to the total number of DEGs within M. Right: In the network plots, DEGs are clustered into M/gene communities based on functional relatedness in the lung tissue. Each DEG is represented by a node within M, and each edge represents a functional association between the pair of DEGs. A node with a larger size reflects a higher degree of connectivity in the network. N, n = 4; MI, n = 5; VI, n = 4.