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. 2021 Oct 15;131(20):e147116. doi: 10.1172/JCI147116

Figure 11. Deletion of Pdgfb in preosteoclasts attenuates HFD-induced vascular stiffening.

Figure 11

PWV (A), systolic BP (B), diastolic BP (C), and mean BP (D) were measured in Pdgfb-cKO and WT littermates after 8 and 14 weeks of a Western HFD. n = 6 to 11. Data are mean ± SEM. *P < 0.05, **P < 0.01 versus WT mice, as determined by 1-way ANOVA with Bonferroni post hoc test. (E) Tensile testing of aortic rings was measured after 14 weeks of a Western HFD diet. n = 10 rings. Data are mean ± SEM. ***P < 0.001 versus WT mice, as determined by 1-way ANOVA with Bonferroni post hoc analysis. (F) Phenylephrine-induced contractility was measured after 14 weeks of a HFD in Pdgfb-cKO and WT littermates. n = 8 to 10 rings. Data are mean ± SEM. **P < 0.01, as determined by 1-way ANOVA with Bonferroni post hoc analysis. (G) Acetylcholine-induced endothelium-dependent relaxation of phenylephrine-preconstricted aortic rings was measured after 14 weeks of a HFD in Pdgfb-cKO and WT littermates. n = 8 to 10 rings. Data are mean ± SEM. **P < 0.01, as determined by 1-way ANOVA with Bonferroni post hoc analysis. (H) The endothelial-independent sodium nitroprusside–induced relaxation was measured after 14 weeks of a HFD in Pdgfb-cKO and WT littermates.