Figure 9. Aortic plasticity and vasoreactivity are impaired in conditional Pdgfb transgenic mice.

(A–D) Tensile testing of aortic rings was measured in 4- and 18-month-old Pdgfb^cTG and WT littermates. n = 10 rings. Data are mean ± SEM, ****P < 0.0001 versus WT mice, as determined by 1-way ANOVA with Bonferroni post hoc analysis. Aortic constriction in response to increasing doses of phenylephrine was measured in the young (E) and aged (F) Pdgfb^cTG mice vs. WT littermates. n = 8 aortic rings. Data are shown as mean ± SEM, *P < 0.05, **P < 0.01, as determined by one-way ANOVA with Bonferroni post hoc test. Endothelium-dependent aortic relaxation in response to increasing doses of acetylcholine was measured in young (G) and aged (H) Pdgfb^cTG mice versus WT littermates. n = 8 aortic rings. Data are mean ± SEM, *P < 0.05, **P < 0.01, as determined by 1-way ANOVA with Bonferroni post hoc test. Endothelium-independent vasorelaxation in response to sodium nitroprusside was measured in young (I) and aged (J) Pdgfb^cTG mice versus WT littermates. n = 8 aortic rings. Data are mean ± SEM.