Table 1.
Baseline Demographic Characteristics and Clinical Features
| Baseline Parameter | Cohort A (n = 8) | Cohort B (n = 8) | Cohort C (n = 8) |
|---|---|---|---|
| Gender (male/female), n/n | 6/2 | 7/1 | 4/4 |
| Ethnicity (Han/other), n/n | 6/2 | 7/1 | 7/1 |
| Age, years | 33.6 ± 9.05 | 36.4 ± 10.56 | 31.5 ± 4.28 |
| Smoking (yes/no), n | 3/5 | 4/4 | 0/8 |
| Drinking (yes/no), n | 0/8 | 2/6 | 0/8 |
| BMI, kg/m2 | 24.30 ± 3.42 | 23.85 ± 3.49 | 23.54 ± 2.07 |
| HBV DNA, log10 IU/mL | 8.24 ± 0.89 | 8.274 ± 0.89 | 8.044 ± 0.49 |
| HBsAg, log10 IU/mL | 4.51 ± 0.67 | 4.21 ± 0.52 | 3.77 ± 0.52 |
| HBeAg, log10 IU/mL | 3.09 ± 0.38 | 2.96 ± 0.53 | 2.50 ± 1.15 |
| HBV pgRNA, log10 copies/mL | 7.50 ± 1.00 | 7.50 ± 1.00 | 7.33 ± 0.61 |
| ALT, U/L | 144 ± 97 | 160 ± 87 | 162 ± 107 |
| FibroScan score | 8.44 ± 4.01 | 9.01 ± 2.40 | 8.15 ± 2.20 |
| AFP,a ng/mL | 4.14(3.07,6.42) | 5.01(2.98,7.03) | 11.61(2.93,23.51) |
| Genotype | B = 1, C = 6, other = 1 | B = 0, C = 5, other = 3 | B = 0, C = 7, other = 1 |
Data are presented as means ± SDs unless otherwise indicated.
Abbreviations: AFP, alpha fetoprotein; ALT, alanine aminotransferase; BMI, body mass index; HBeAg, hepatitis B e antigen; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus; pgRNA, pregenomic RNA; Q1, quartile1; Q3, quartile3.
aValues are medians (Q1, Q3).