Table 3.

Association Between Bivalent Human Papillomavirus Vaccination and Anogenital Warts Diagnosed by General Practitioners, Stratified by Birth Cohort

Vaccination Status	No.a	Observation Time, y	AGW Diagnoses	aIRRb (95% CI)	aIRRc (95% CI)
Cohorts 1996–2002d
Unvaccinated	51 454	91 815	85	Reference	Reference
Vaccinated (≥ 1 dose)	41 921	116 874	93	0.68 (.51–.91)	0.69 (.51–.93)
Unvaccinated	51 454	91 815	85	Reference	Reference
Partially vaccinatede	28 022	20 219	20	1.99 (1.18–3.19)	1.47 (.86–2.40)
Fully vaccinatede	38 381	96 655	73	0.58 (.42–.79)	0.60 (.44–.83)
Cohorts 1993–1995d
Unvaccinated	15 033	52 314	211	Reference	Reference
Vaccinated (≥ 1 dose)	16 378	63 623	217	0.79 (.65–.95)	0.77 (.64–.93)
Unvaccinated	15 033	52 314	211	Reference	Reference
Partially vaccinatede	3768	6190	22	0.92 (.57–1.39)	0.80 (.50–1.22)
Fully vaccinatede	15 008	57 433	195	0.78 (.64–.94)	0.77 (.63–.93)

Abbreviations: AGW, anogenital warts; aIRR, adjusted incidence rate ratio; CI, confidence interval.

^aNumber of women who contributed observation time per vaccination status. One woman could contribute observation time to > 1 vaccination status. Women with a missing educational level were excluded.

^bAdjusted for age as time-varying.

^cAdjusted for age as time-varying, migration background, educational level, fear of sexually transmitted infection/human immunodeficiency virus consultations, and mean number of general practitioner consultations per year.

^dBirth cohorts 1996–2002 were 12–13 years old when vaccination was offered. Birth cohorts 1993–1995 were 13–16 years old when vaccination was offered.

^ePartially vaccinated: 1 dose or 2 doses < 5 months apart. Fully vaccinated: 3 doses or 2 doses ≥ 5 months apart.